About Tirzepatide
Tirzepatide is a 39-amino-acid dual GLP-1 and GIP receptor agonist that produced 22.5% weight loss at 72 weeks in SURMOUNT-1. Reduces liver fat by 47% over 72 weeks in the substudy.
Reported benefits
- Drives 22.5% weight loss at 72 weeks (SURMOUNT-1)
- Reduces hepatic fat by 47% over 72 weeks
- Preserves lean mass better than mono-agonists
Research citations
- Jastreboff et al. 2022 - NEJM (SURMOUNT-1)
- Gastaldelli et al. 2023 - Lancet Diabetes
How Tirzepatide fits the category
Tirzepatide sits inside the Best Peptides for Weight Loss category. For the full ranking and head-to-head comparisons, read Best Peptides for Weight Loss.

