About MOTS-c
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by the 12S rRNA region of mitochondrial DNA. Raises mitochondrial ATP synthesis by 1.8× and increases skeletal-muscle glucose uptake by 60%.
Reported benefits
- Raises ATP synthesis by 1.8× in skeletal muscle
- Increases glucose uptake by 60% via AMPK
- Restores exercise capacity by 23% in aged subjects
Research citations
- Lee et al. 2015 - Cell Metabolism
- Reynolds et al. 2021 - Nature Communications
How MOTS-c fits the category
MOTS-c sits inside the Best Peptides for Energy category. For the full ranking and head-to-head comparisons, read Best Peptides for Energy.

